Optimization in Drug Discovery - (Methods in Pharmacology and Toxicology) 2nd Edition by Gary W Caldwell & Zhengyin Yan (Hardcover)
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<p/><br></br><p><b> About the Book </b></p></br></br><p>This fresh edition features new assay variations and the latest protocols for optimizing drug discovery. With expert tips and troubleshooting advice, and revised throughout for this second edition, it covers cutting-edge techniques such as cytochrome P450.</p><p/><br></br><p><b> Book Synopsis </b></p></br></br><p>Thoroughly revised and updated, <i>Optimization in Drug Discovery: In Vitro Methods, Second Edition</i> presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the <i>Methods in Pharmacology and Toxicology</i> series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve "drug-like" characteristics in addition to efficacy properties and good safety profiles of drug candidates.</p><p>Comprehensive and up-to-date, <i>Optimization in Drug Discovery: In Vitro Methods, Second Edition</i> aims to guide researchers down the difficult path to successful drug discovery and development.</p><p/><br></br><p><b> From the Back Cover </b></p></br></br><p>Thoroughly revised and updated, <i>Optimization in Drug Discovery: In Vitro Methods, Second Edition</i> presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the <i>Methods in Pharmacology and Toxicology</i> series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve "drug-like" characteristics in addition to efficacy properties and good safety profiles of drug candidates. </p><p> </p>Comprehensive and up-to-date, <i>Optimization in Drug Discovery: In Vitro Methods, Second Edition</i> aims to guide researchers down the difficult path to successful drug discovery and development.
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