Routes to Essential Medicines - by Peter J Harrington (Paperback)
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<p/><br></br><p><b> About the Book </b></p></br></br>"Organic synthesis concentrates on the building of organic compounds. The process involves using simple molecules to construct complex organic molecules. Due to its intricate nature, organic synthesis is considered one of the most important branches of organic chemistry. It allows chemists to create new structures with the potential to solve real world problems. The discovery of new organic compounds that can be utilized for biomedical purposes is significant to medicinal chemical research. Pharmaceutical development benefits largely from the study of organic synthesis and there is high demand for new synthetic methodologies"--<p/><br></br><p><b> Book Synopsis </b></p></br></br><p>This comprehensive workbook helps readers become familiar with the structures and synthetic challenges associated with nearly 300 essential medicines and gain the skills needed for pharmaceutical development.</p> <ul> <li>Highlights nearly three hundred medicines on the latest World Health Organization (WHO) Model List of Essential Medicines and their manufacturing routes</li> <li>Features exercises that equip students with the skills necessary to solve similar real-world problems</li> <li>Includes a retrosynthetic analysis for each commodity chemical and supplies an extensive list of key journal and information sites and a library of reagents, solvents, and conditions for many common organic reactions</li> </ul><p/><br></br><p><b> From the Back Cover </b></p></br></br><p><b>A comprehensive, hands-on workbook covering the structures and manufacture of essential medicines</b></p> <p><i>Routes to Essential Medicines: A Workbook for Organic Synthesis</i> familiarizes students with the structures and strategies for synthesis of hundreds of essential medicines and their component commodity chemicals. Helping readers develop the skills needed for pharmaceutical development, this workbook includes all the medicines on the 2017 World Health Organization (WHO) Model List of Essential Medicines that involve synthetic organic chemistry in the manufacturing process. <p>Alphabetically organized by INN (International Non-Proprietary Name), each entry for a particular essential medicine includes the structure of the target molecule, the indications for the drug taken from the WHO Model List, and the manufacturing route with the shortest sequence from starting materials to target molecule. The workbook provides a strategy for readers to search for the reagents, solvents, conditions, and mechanism for each reaction and to evaluate the overall route. Encompassing a diverse range of pharmaceutical compounds, this comprehensive workbook: <ul><li>Highlights the synthetic organic chemistry in the manufacturing routes of approximately 300 essential medicines </li> <li>Helps readers gain a better understanding of the manufacture of specialty chemical starting materials</li> <li>Enables readers to build an up-to-date listing of key journal and information sites, and an extensive library of reagents, solvents, and conditions for numerous organic reactions</li> <li>Features numerous exercises that mirror real-world problems, and sections that task students to propose and evaluate alternative routes, reactions, or reagents</li> <li>Includes several appendices containing a retrosynthetic analysis for each specialty chemical, and listings of the biochemicals and petrochemicals used in the workbook</li></ul> <p>Designed to facilitate active engagement, <i>Routes to Essential Medicines: A Workbook for Organic Synthesis</i> is an ideal practical resource for students in organic synthesis and medicinal chemistry courses, as well as a useful reference for chemists, scientists, and researchers in both academia and industry studying the medicinal, process, and manufacturing of essential medicines.<p/><br></br><p><b> About the Author </b></p></br></br><p><b>Peter J. Harrington, PhD, </b> is the owner and primary consultant for Better Pharma Processes LLC, Boulder, Colorado, USA. Dr. Harrington is a pharmaceutical process design and development expert with more than twenty years' experience in timely process innovation for major pharmaceuticals. His publications include a book on pharmaceutical process chemistry for synthesis and several articles on organic and medicinal chemistry.</p>
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