Human Drug Metabolism - 3rd Edition by Michael D Coleman (Paperback)
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<p/><br></br><p><b> About the Book </b></p></br></br>"The third edition of this key text continues to provide an invaluable introduction to the core areas of pharmacology, and covers recent progress and advances in this fast moving field. It will continue to cover basic concepts of teaching drug metabolism starting from extreme clinical consequences to systems and mechanisms and toxicity. The new edition will retain this basic layout, but will be fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact. It will also reflect refinements in the author's own teaching methods, particularly with respect to helping students to understand biological systems and how they operate so they can be seen as predictable, rather than the usual default rote-learning approach that many adopt. This approach has usually been confined to life-science students who might gravitate to research. However, the author is hoping to also help clinically active individuals, by enabling them to grasp a more sophisticated approach to drug metabolism and retain it to augment their professional performance"--<p/><br></br><p><b> Book Synopsis </b></p></br></br><p><b>Provides a timely update to a key textbook on human drug metabolism</b></p> <p>The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact.</p> <p><i>Human Drug Metabolism, 3rd Edition</i> begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s.</p> <ul> <li>Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact</li> <li>Reflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate</li> <li>Illustrates the growing relationship between drug metabolism and personalized medicine</li> <li>Includes recent developments in drug discovery, genomics, and stem cell technologies</li> </ul> <p><i>Human Drug Metabolism, 3rd Edition</i> is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.</p><p/><br></br><p><b> From the Back Cover </b></p></br></br><p><b>Provides a timely update to a key textbook on human drug metabolism</b> <p>The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact. <p><i>Human Drug Metabolism, Third Edition</i> begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of Pharmacology to Physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s. <ul> <li>Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact</li> <li>Reflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate</li> <li>Illustrates the growing relationship between drug metabolism and personalized medicine</li> <li>Includes recent developments in drug discovery, genomics, and stem cell technologies</li> </ul> <p><i>Human Drug Metabolism, Third Edition</i> is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.<p/><br></br><p><b> About the Author </b></p></br></br><p><b>Michael D. Coleman</b>, Presently Professor of Toxicology at Aston University. During his career, Dr. Coleman has studied and worked at Liverpool University, The Liverpool School of Tropical Medicine, Walter Reed Army Institute of Research in Washington D.C. and latterly Aston University. His substantial and original contribution to knowledge of the biochemical pharmacology and toxicology of antiparasitic drugs has been acknowledged in the award of the degree of Doctor of Science in 2005.
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