Enzyme Systems That Metabolise Drugs and Other Xenobiotics - (Current Toxicology) by Costas Ioannides (Hardcover)
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<p/><br></br><p><b> Book Synopsis </b></p></br></br>In den letzten Jahren haben wir neue Erkenntnisse über metabolische und toxikologische Aspekte metabolisierender Enzymsysteme gewonnen. Dieser Band gehört zur Reihe 'Current Toxicology Series' und ist das erste maßgebliche Nachschlagewerk, das sich kritisch mit Enzymsystemen auseinandersetzt, die am Metabolismus von Chemikalien und anderer Xenobiotika beteiligt sind. Ein deutlicher Schwerpunkt liegt dabei auf dem Medikamentenstoffwechsel. Jedes Kapitel behandelt ein spezifisches Enzymsystem und diskutiert detailliert die metabolischen und toxikologischen Aspekte des metabolisierenden Enzymsystems. Das Handbook of Enzyme Systems for Drugs and other Xenobiotics ist eine einzigartige Informationsquelle, denn es setzt sich speziell mit dem Thema der Wirkstoff-Forschung und -Entwicklung auseinander. Geschrieben von führenden internationalen Experten auf diesem Gebiet.<p/><br></br><p><b> From the Back Cover </b></p></br></br>This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include: <br /> * enzyme function in the metabolism and bioactivation of xenobiotics<br /> <br /> * substrate specificity<br /> <br /> * tissue distribution<br /> <br /> * species distribution (to include laboratory animals and humans)<br /> <br /> * hormonal regulation<br /> <br /> * sex differences<br /> <br /> * modulation by prior exposure to other chemicals<br /> <br /> * age-dependent expression<br /> <br /> * pharmacogenetics and modulation by disease.<br /> Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.<p/><br></br><p><b> Review Quotes </b></p></br></br><br>an invaluable reference book (ISSX Newsletter, Summer 2002)<br><p/><br></br><p><b> About the Author </b></p></br></br><strong>Costas Ioannides</strong> is the author of Enzyme Systems that Metabolise Drugs and Other Xenobiotics, published by Wiley.
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